Inhibition of Ras‐expressing Keratinocytes by De‐epidermized Dermis
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چکیده
منابع مشابه
Tonic Inhibition of TRPV3 by Mg2+ in Mouse Epidermal Keratinocytes
The transient receptor potential vanilloid 3 channel (TRPV3) is abundantly expressed in epidermal keratinocytes and has important roles in sensory biology and skin health. Mg(2+) deficiency causes skin disorders under certain pathological conditions such as type 2 diabetes mellitus. In this study, we investigated the effect of Mg(2+) on TRPV3 in primary epidermal keratinocytes. Extracellular Mg...
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BACKGROUND Mammalian target of rapamycin (mTOR) inhibitors are associated with dermatological adverse events. The chief aim of this study was to examine the relation between the signal transducer and activator of transcription 3 (STAT3) protein and the dermatological adverse events associated with the mTOR inhibitor everolimus. METHODS We evaluated the effects of STAT3 activity and related si...
متن کامل-induced growth inhibition of human epidermal keratinocytes
1 Department of Cell Biology, 2 Department of Bacteriology, and 3 Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan 4 Department of Medical Engineering, Kawasaki Medical School, Okayama 701-0192, Japan 5 Department of Bioscience and Biotechnology, Okayama University Graduate School of Natural Science and Technology, Okayama 700-8530...
متن کاملCollagenase production by human dermis in vitro.
Isolated human dermis has been shown to produce a specific collagenase in vitro. Enzyme activity becomes detectable after two days of culture, reaches a peak on the fourth day, and then begins to decline. Like collagenase obtained from cultures of whole human skin, dermal collagenase is inhibited by human serum and EDTA. The possible sources of this enzyme are discussed. Collagenolytic activity...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.830.5